The manufacturing process of creatine ethyl ester hydrochloride is a manufacturing method

Patent name: Preparation method of manufacturing process of creatine ethyl ester hydrochloride.

Technical Field:

The present invention relates to a manufacturing process of creatine ethyl ester hydrochloride.

Background technology:

In the known literature, such as the research report of A.W. Dox and L.Yoder published in the American Journal of Biochemistry, the research report co-authored by J.O.MOLD and R.C.GORE and others published in the Journal of the American Chemical Society, and the preparation of creatine ethyl ester hydrochloride expressed in Japan Chartered Akira 32-9076 and 32-9078, the dried creatine is placed in absolute ethanol, hydrogen chloride is introduced at room temperature to saturation, stirred for several hours to precipitate crystals, and then it is filtered. Hydrogen chloride gas is sucked to obtain creatine ethyl hydrochloride. However, the hydrogen chloride and hydrogen chloride in ethanol are saturated, which makes the consumption of hydrogen chloride exceed the actual consumption by 8 to 10 times, which is not only easy to cause environmental pollution and material loss, but also the presence of a large amount of hydrogen chloride will absorb more water, making the product difficult to dry, and also increases the chance of generating muscle hydrochloride, thereby reducing the purity of the product.

Contents of the invention

The purpose of this discovery is to bring a class of hydrogen chloride to the economical production of creatine ethyl hydrochloride.

The technical requirement of this innovation is a kind of creatine ethyl ester hydrochloride production and processing process, which has the following method steps, the ethanol with hydrogen chloride above the concentration value of 99% is mixed into a solvent, wherein, the total weight ratio of hydrogen chloride is 8%~10%; Dry creatine is put into the mixed solvent, and creatine ethyl ester hydrochloride is formed after stirring, in which the total weight of ethanol and creatine is 7.5:1~8.5:1; The synthesized creatine ethyl ester hydrochloride is separated from the ethanol and hydrogen chloride solvent to obtain creatine ethyl hydrochloride.

Compared with the existing process, this innovation has the following advantages: firstly, according to the total weight, the mixed solvent of ethanol and hydrogen chloride is prepared, and then a certain amount of creatine is put into the mixed solvent according to the specification to do a good chemical reaction, and then the creatine ethyl ester hydrochloride obtained by the chemical reaction is separated at the end, considering that the total weight of ethanol, hydrogen chloride and creatine is to be prepared according to the chemical reaction, so the excess hydrogen chloride gas can be prevented from being introduced into the mixed solvent, and the loss of raw materials is reduced, In addition, the product after the chemical reaction can be directly peeled off and dry, and the probability of forming impurities such as creatinine hydrochloride in the chemical reaction method step is also small, and the product with high purity can be obtained.

The above is an overview of the manufacturing process of creatine ethyl ester hydrochloride, friends can learn about it.