Method and process for synthesizing glycine propionylcarnitine hydrochloride

　Glycine propionylcarnitine hydrochloride is a drug for the treatment of cardiovascular diseases and functional disorders, and its internal salt and hydrochloride have neuroprotective and neuro-promoting functions, which are very effective for patients with Alzheimer's disease, elderly depression and memory impairment, and can significantly improve the left ventricular function of congestive heart failure. In addition, it is also an intermediate synthesized by many drugs, let's learn about the method and process of synthesizing glycine propionylcarnitine hydrochloride!

　Among them, glycine propionylcarnitine hydrochloride is a hygroscopic product, which requires the use of a humidity control room during storage and processing; Levocarnitine propionate hydrochloride does not easily absorb moisture, which is convenient for storage and transportation and preparation of solid preparations. Glycine is the simplest amino acid and is commonly used in foods, seasonings, and nutraceuticals. The double salt glycine, propionylcarnitine hydrochloride (GPLC) formed from glycine and propionylcarnitine, is a non-hygroscopic salt that can improve therapeutic and/or nutritional value, and is very stable, easy to store and transport, convenient for the preparation of solid dosage forms, and has broad application prospects

The preparation method of glycine propionylcarnitine hydrochloride, namely glycine hydrochloride (hygroscopic product) and propionylcarnitine inner salt) is dissolved in a small amount of water and concentrated in vacuum, and dried by extraction, filtration and drying is obtained to obtain a non-hygroscopic white crystalline solid - glycine carnitine hydrochloride with a yield of 94 The raw materials used in this method are glycine hydrochloride, that is, glycine hydrochloride, and propionylcarnitine inner salt, which is propionylcarnitine inner salt, both of which are hygroscopic products, which are not easy to preserve, and have high requirements for storage and processing environment, which bring inconvenience to industrial production.

The solvent used in this method is water, which is not conducive to recycling and reuse, and has a certain degree of harm to the environment; Before extraction, it needs to go through a concentration process, which is complicated to operate. In addition, propionyl L-carnitine hydrochloride is obtained from propionyl L-carnitine hydrochloride, which significantly increases the manufacturing process, so the cost is higher than that of propionyl L-carnitine hydrochloride at the same molar amount; The market price of glycine hydrochloride is also higher than that of glycine. Therefore, there is an urgent need to develop a preparation method for glycidyl carnitine hydrochloride that is easy to operate, more suitable for industrial production, environmentally friendly and low-cost.

In order to solve the above problem, the present invention discloses a new method for synthesizing glycine, propionyl group, levocarnitine hydrochloride. A method for synthesizing glycine, propionylcarnitine hydrochloride comprises the following processes:

1) dissolve propionylcarnitine hydrochloride with an organic solvent;

2) Add glycine, raise the temperature to 50-100 to make it react for 0.5-5 hours;

3) Cooling crystallization and separation to obtain precipitated crystals;

The above is the method and process for synthesizing glycine propionylcarnitine hydrochloride, although the principle and embodiment of the present invention applicable to specific embodiments are described in this specification, but the description of the above embodiments is to help understand the method of the present invention and its central idea. In addition, for those skilled in the art, without departing from the principle of the present invention, some improvements and changes can also be made to the present invention, and these improvements and changes are also included in the protection of the claims of the present invention.