The role and efficacy of L-ornithine ketoglutarate

　Ornithine is one of the three amino acids involved in the urea cycle, the other two are L-arginine and L-citrulline, this amino acid seems to reduce the level of ammonia that rises during supplementation, so let's learn about the role and efficacy of L-ornithine ketoglutarate!

　L-Ornithine Ketoglutarate is an intermediate of the urea cycle – a non-protein amino acid (not used for protein production), and the supply of ornithine to cells is effectively a rate-limiting step in this cycle.

L-ornithine ketoglutarate is thought to be important for conditions characterized by excess ammonia, mainly in hepatic encephalopathy (clinical liver disease) and long-term cardiovascular exercise. In patients with hepatic encephalopathy, repeated ammonia reductions have been found (most studies used infusions, but appear to be suitable for high-dose oral complementary foods as well). It is not an acute exercise, but a long time of use in exercise, and it does have the effect of relieving fatigue.

In addition, patients with hepatic encephalopathy and hangovers (a process in which alcohol consumption leads to an increase in serum ammonia) can see a reduction in self-reported fatigue when taking ornithine before drinking, but only in those who are sensitive to alcohol.

Ornithine appears to be promising to improve performance during prolonged exercise (more than 45 minutes) by lowering ammonia concentrations in the blood.

It has been noted that ornithine supplementation (100 mg/kg as hydrochloride supplementation) prior to follow-through exercise can significantly increase plasma glutamate concentrations at rest and after vigorous exercise.

The accumulation of ammonia in skeletal muscle, which induces muscle fatigue after muscle protein contraction inhibition, usually accumulates in the serum and brain during exercise, and then in the brain, thereby promoting feelings of fatigue.

　One study found that adult men who received strength training gained lean body mass over 5 weeks with the same amount of L-arginine (total 2 g or 4 g) as 1 g or 2 g of L-ornithine.

The anti-fatigue effects of ornithine appear to occur only during prolonged exercise, which is related to the time when ammonia usually causes problems.

We note that the injection (injection) of ornithine is dependent on the hypothalamus to increase circulating growth concentrations. It was noted that pairing 2200 mg of ornithine, 3000 mg of arginine and 12 mg of B12 for 3 weeks resulted in a 35.7% increase in plasma growth concentration (measured immediately after exercise), which decreased after 1 hour of increase, but was higher than that of placebo.

In 12 bodybuilders, studies that received an acute dose of 40, 100 or 170 mg/kg of ornithine hydrochloride noted that only the highest dose (170 mg/kg or 70 kg of 12 g for men) increased GH concentrations after 90 minutes. 318% higher than baseline, with no significant effect at 45 minutes.

Ornithine supplementation, after supplementation, can cause a sharp increase in growth secretion. However, since the interaction of arginine with growth, especially from the point of view that an acute increase does not bring a one-day benefit, also applies to ornithine, these results may not actually be related.

Due to ornithine's ability to stimulate the urea cycle, promote ammonia excretion, and the rapid rise in ammonia concentrations due to alcohol consumption (and there is evidence that ornithine may help reduce symptoms of hangovers, drunkenness) L-ornithine-ketoglutarate (specific) is a precursor to arginine and glutamine, and therefore proline, which is also thought to be beneficial for healing, but this is usually not a problem), the 2 precursor amino acids are useful as intestinal additions in clinical settings

The above is the role and efficacy of L-ornithine ketoglutarate, which has been studied in the vein of L-ornithine-ketoglutarate, in which the speed of healing is accelerated, if you want to know more, you can contact us at any time!